Metabolic - Marek Doyle

adrenal

Chronic Inflammatory Conditions: How Cortisol Actually Works, Why It Depends on the Mitochondria (and Where Licorice, Adaptogens and the Organic Acids Test Fit In)

TLDR: Cortisol is the primary anti-inflammatory agent in our bodies, but depends on the mitochondria to deliver this effect Long-term stress reliably results in a loss of cortisol activity, an increase in nitric oxide and hypoxia at the mitochondria Interventions must target both cortisol activity

adrenaline

How Does Stress Affect The Body? 3 Ways It Impacts Us, 6 Action Points

The idea that stress has a negative effect on the body is hardly new and not an idea that is in dispute. But how does such an idea help us in taking action? This is where it can be helpful to acknowledge that stress can

Q&A: Why Do I React Badly to Saunas?

TRANSCRIPT: Today's subject: saunas. But I want to touch on angle that gets very little coverage, which is: what if you feel worse after taking them? Now this follows a question I received on email, which asks pretty much exactly that. But before I touch

adrenal

Semaglutide: Mechanism, Questions and Future Discussion Points

TRANSCRIPT: It started its life as a diabetes medication. More recently, it's been referred to as a celebrity weight loss drug. And since NICE - the National Institute of Clinical Excellence - have approved it for NHS prescription, it's also been the subject of several

heart rate variability

Heart Variability and Stress Explained: How to Measure It, Healthy Ranges, How to Increase It

Heart Rate Variability became an area of interest during the 70s, when it was deployed to monitor the health of newborn babies as well as to track recovery rates of athletes. Since this time, it has been shown to provide insights on the overall health

Why can’t I meditate? Discussion of the neurobiological obstacles faced by those with ME/CFS (and other inflammatory / energetic / stress disorders)

Western medicine may be late to the party but, in recent years, as begun to cultivate a relationship with meditation. And the early signs are decidedly positive; as more and more randomized controlled trials are performed, researchers are finding that meditation reduces inflammation, reduces anxiety,

cellular hypothyroidism

Low thyroid symptoms with normal lab results: what four decades of science says about the value of testing TSH and T4, recognizing cellular hypothyroidism and treatment options

Undertake any search of ‘consequences of hypothyroidism’ and you will reliably receive a laundry list of the usual symptoms; fatigue, brain fog, low mood, constipation, sensitivity to the cold, reduced hair growth and general malaise. However, the impact of hypothyroidism in the human body cannot

Is cortisol good or bad? Implications for adrenal support in ME/CFS, stress-related and inflammatory conditions

Cortisol is associated with neurotoxicity and subsequent depression, with papers showing that sustained high cortisol is associated with reduced neuroplasticity. Studies that supply animals with Prednisolone, a synthetic cortisol analog and therefore a member of the glucocorticoid family, reliably show depressive behaviours (see Gonzalez-Perez et

c8 oil

Ketogenic Diet FAQs

Ketosis is an alternative means of fueling the body and one where ketones act as the primary fuel for the central nervous system (your brain). The switch to this alternative fueling state occurs when carbohydrate availability drops and fats remain plentiful; this is important because

brain fog

Research Says that High-Fat Meals Cause Endotoxemia and Brain Fog… Except It Didn’t

From treating non-responsive epilepsy or through maintaining performance at high altitude, the benefits of ketogenic diets have been known for many decades. However, it is in the last few years that interest in this approach has skyrocketed and has induced the usual responses in the